THE WHATDX CASE GUIDE LIBRARY
A starting point for health questions that haven't been settled.
Find a guide that resembles your question. Each explains what an earlier test may not have answered and lets you try a free, three-question research screen. These pages organize research priorities, not diagnoses.
Immunology & Derm
Recurrent hives despite normal allergy tests | WhatDxWhatDx research guide: recurrent hives despite normal allergy tests. See what to observe, which records may matter, and what focused question to High eosinophils with a persistent skin rash | WhatDxWhatDx research guide: high eosinophils with a persistent skin rash. See what to observe, which records may matter, and what focused question to Adult-onset eczema that is not improving with steroid cream | WhatDxWhatDx research guide: adult-onset eczema that is not improving with steroid cream. See what to observe, which records may matter, and what focusRecurrent mouth ulcers with joint pain and normal routine blood tests | WhatDxWhatDx research guide: recurrent mouth ulcers with joint pain and normal routine blood tests. See what to observe, which records may matter, and
Neurology & Nerve
Burning feet or neuropathy symptoms despite normal EMG/MRI | WhatDxWhatDx research guide: burning feet or neuropathy symptoms despite normal emg/mri. See what to observe, which records may matter, and what focuseDizziness and a racing heart when standing despite a normal ECG | WhatDxWhatDx research guide: dizziness and a racing heart when standing despite a normal ecg. See what to observe, which records may matter, and what fMorning headaches despite a normal brain MRI | WhatDxWhatDx research guide: morning headaches despite a normal brain mri. See what to observe, which records may matter, and what focused question to Internal tremors or muscle twitching despite normal tests | WhatDxWhatDx research guide: internal tremors or muscle twitching despite normal tests. See what to observe, which records may matter, and what focused
GI & Metabolic
Persistent reflux symptoms despite a normal endoscopy and PPI treatment | WhatDxWhatDx research guide: persistent reflux symptoms despite a normal endoscopy and ppi treatment. See what to observe, which records may matter, anChronic diarrhea despite a normal colonoscopy | WhatDxWhatDx research guide: chronic diarrhea despite a normal colonoscopy. See what to observe, which records may matter, and what focused question toEarly fullness, nausea or bloating despite normal endoscopy/ultrasound | WhatDxWhatDx research guide: early fullness, nausea or bloating despite normal endoscopy/ultrasound. See what to observe, which records may matter, andPersistently elevated liver enzymes despite a normal ultrasound | WhatDxWhatDx research guide: persistently elevated liver enzymes despite a normal ultrasound. See what to observe, which records may matter, and what f
Rheum & Endocrine
Joint pain or swelling despite normal CRP/ESR and negative ANA | WhatDxWhatDx research guide: joint pain or swelling despite normal crp/esr and negative ana. See what to observe, which records may matter, and what foPositive ANA with fatigue or joint pain but normal CRP | WhatDxWhatDx research guide: positive ana with fatigue or joint pain but normal crp. See what to observe, which records may matter, and what focused quHypothyroid-like symptoms despite a normal TSH | WhatDxWhatDx research guide: hypothyroid-like symptoms despite a normal tsh. See what to observe, which records may matter, and what focused question tBone or joint pain with persistently low alkaline phosphatase | WhatDxWhatDx research guide: bone or joint pain with persistently low alkaline phosphatase. See what to observe, which records may matter, and what focRecurrent unexplained fevers after negative infection testing | WhatDxWhatDx research guide: recurrent unexplained fevers after negative infection testing. See what to observe, which records may matter, and what foc
Pediatrics
A child with leg pain during running or hopping | WhatDxWhatDx research guide: a child with leg pain during running or hopping. See what to observe, which records may matter, and what focused question A child with recurrent stomach pain despite normal ultrasound/blood tests | WhatDxWhatDx research guide: a child with recurrent stomach pain despite normal ultrasound/blood tests. See what to observe, which records may matter, Recurrent lip/eye swelling with abdominal pain and normal allergy tests | WhatDxWhatDx research guide: recurrent lip/eye swelling with abdominal pain and normal allergy tests. See what to observe, which records may matter, an
Gastroenterology
Ferritin and hemoglobin refusing to rise after months of oral iron tabletsFerritin and hemoglobin refusing to rise after months of oral iron tablets. Compare evidence and try a free three-question research guide.Abdominal distension, gas, and brain fog that worsen after taking probiotics or fiberAbdominal distension, gas, and brain fog that worsen after taking probiotics or fiber. Compare evidence and try a free three-question research guRight upper quadrant pain returning months or years after gallbladder removalRight upper quadrant pain returning months or years after gallbladder removal. Compare evidence and try a free three-question research guide.Severe post-meal upper abdominal pain with normal endoscopy and ultrasoundSevere post-meal upper abdominal pain with normal endoscopy and ultrasound. Compare evidence and try a free three-question research guide.Gastritis burning and bloating persisting after completing h. pylori antibiotic therapyGastritis burning and bloating persisting after completing H. pylori antibiotic therapy. Compare evidence and try a free three-question research Severe chronic constipation unresponsive to osmotic laxatives and high fiberSevere chronic constipation unresponsive to osmotic laxatives and high fiber. Compare evidence and try a free three-question research guide.Daily morning nausea and early satiety with normal routine blood work and endoscopyDaily morning nausea and early satiety with normal routine blood work and endoscopy. Compare evidence and try a free three-question research guid
Spine & Rheumatology
Lower back pain and stiffness emerging or worsening after stopping alcoholLower back pain and stiffness emerging or worsening after stopping alcohol. Compare evidence and try a free three-question research guide.Back pain flaring after physiotherapy despite a reassuring lumbar spine mriBack pain flaring after physiotherapy despite a reassuring lumbar spine MRI. Compare evidence and try a free three-question research guide.Severe joint pain and stiffness rebounding within days of finishing a steroid courseSevere joint pain and stiffness rebounding within days of finishing a steroid course. Compare evidence and try a free three-question research guiBilateral heel or achilles pain failing orthotics, physiotherapy, and injectionsBilateral heel or Achilles pain failing orthotics, physiotherapy, and injections. Compare evidence and try a free three-question research guide.Radiating sciatic leg pain and burning despite a lumbar mri showing no nerve root compressionRadiating sciatic leg pain and burning despite a lumbar MRI showing no nerve root compression. Compare evidence and try a free three-question resDeep bone and muscle pain persisting after normalizing vitamin d with normal esr/crpDeep bone and muscle pain persisting after normalizing Vitamin D with normal ESR/CRP. Compare evidence and try a free three-question research guiSevere neck heaviness, occipital headache, and dizziness with mild or normal cervical mriSevere neck heaviness, occipital headache, and dizziness with mild or normal cervical MRI. Compare evidence and try a free three-question researcAcute joint flares continuing months after starting uric-acid lowering medicationAcute joint flares continuing months after starting uric-acid lowering medication. Compare evidence and try a free three-question research guide.Sudden inability to raise arms or get out of bed in adults over 50 with normal x-raysSudden inability to raise arms or get out of bed in adults over 50 with normal X-rays. Compare evidence and try a free three-question research gu
Dermatology
Relentless full-body itching (pruritus) with clear skin that does not respond to allergy pillsRelentless full-body itching (pruritus) with clear skin that does not respond to allergy pills. Compare evidence and try a free three-question reThick scalp scaling, redness, and shedding failing ketoconazole and anti-dandruff shampoosThick scalp scaling, redness, and shedding failing ketoconazole and anti-dandruff shampoos. Compare evidence and try a free three-question researStubborn body or groin ringworm relapsing repeatedly after oral itraconazole or terbinafineStubborn body or groin ringworm relapsing repeatedly after oral itraconazole or terbinafine. Compare evidence and try a free three-question reseaAdult jawline acne, hair thinning, and chin hair despite a normal pelvic ultrasound and total testosteroneAdult jawline acne, hair thinning, and chin hair despite a normal pelvic ultrasound and total testosterone.Unexplained frequent bruising on legs and arms with normal cbc platelets, pt, and apttUnexplained frequent bruising on legs and arms with normal CBC platelets, PT, and aPTT. Compare evidence and try a free three-question research g
Neurology
Chronic daily headache that stopped responding to migraine meds and changes with postureChronic daily headache that stopped responding to migraine meds and changes with posture. Compare evidence and try a free three-question researchNeurological symptoms or low b12/copper blood levels failing to resolve on supplementsNeurological symptoms or low B12/copper blood levels failing to resolve on supplements. Compare evidence and try a free three-question research gRecurrent dizziness, rocking sensation, or vertigo where epley maneuvers and betahistine failRecurrent dizziness, rocking sensation, or vertigo where Epley maneuvers and betahistine fail. Compare evidence and try a free three-question resWidespread muscle twitching (fasciculations) and cramps with a normal neurological exam and emgWidespread muscle twitching (fasciculations) and cramps with a normal neurological exam and EMG. Compare evidence and try a free three-question rPersistent one-sided facial, cheek, or tooth pain where dental work and carbamazepine failedPersistent one-sided facial, cheek, or tooth pain where dental work and carbamazepine failed. Compare evidence and try a free three-question reseSevere word-finding difficulty, brain fog, and fatigue in an adult under 45 with a normal brain mriSevere word-finding difficulty, brain fog, and fatigue in an adult under 45 with a normal brain MRI. Explore the earlier tests and three-questionIntermittent double vision or heavy eyelids worse in the evening with a normal brain mri and negative achrIntermittent double vision or heavy eyelids worse in the evening with a normal brain MRI and negative AChR.
Systemic Conditions & Lab Findings
Markedly elevated esr (>50 mm/hr) paired with a completely normal crpMarkedly elevated ESR (>50 mm/hr) paired with a completely normal CRP. Compare evidence and try a free three-question research guide.Mildly elevated blood calcium (10.3–11.0 mg/dl) paired with a 'normal' (non-suppressed) pthMildly elevated blood calcium (10.3–11.0 mg/dL) paired with a 'normal' (non-suppressed) PTH. Compare evidence and try a free three-question reseaSudden blood pressure spikes or resistant hypertension under age 45 despite 2+ medicationsSudden blood pressure spikes or resistant hypertension under age 45 despite 2+ medications. Compare evidence and try a free three-question researRapid central weight gain, puffy face, and insomnia with a 'normal' 8 am blood cortisol testRapid central weight gain, puffy face, and insomnia with a 'normal' 8 AM blood cortisol test. Compare evidence and try a free three-question reseElevated serum ferritin (>400–1000 ng/ml) when serum iron and transferrin saturation are normal or lowElevated serum ferritin (>400–1000 ng/mL) when serum iron and transferrin saturation are normal or low.Unrefreshing 9-to-10-hour sleep and severe daytime exhaustion with completely normal blood panelsUnrefreshing 9-to-10-hour sleep and severe daytime exhaustion with completely normal blood panels. Explore the earlier tests and three-question c
Heart, Lungs & Urogenital Health
Burning urination, urgency, and pelvic pain with repeatedly 'negative' standard urine culturesBurning urination, urgency, and pelvic pain with repeatedly 'negative' standard urine cultures. Compare evidence and try a free three-question reAir hunger and inability to get a satisfying deep breath with 99% oxygen, normal x-ray, and normal echoAir hunger and inability to get a satisfying deep breath with 99% oxygen, normal X-ray, and normal Echo.Dry cough lasting >8 weeks failing asthma inhalers, allergy pills, and antibiotics with a clear chest x-rayDry cough lasting >8 weeks failing asthma inhalers, allergy pills, and antibiotics with a clear chest X-ray.Daily sinus pressure, congestion, and facial pain failing antibiotics and sprays with a clear sinus ctDaily sinus pressure, congestion, and facial pain failing antibiotics and sprays with a clear Sinus CT.Recurrent chest tightness or exertional pain after cardiologist cleared a 'normal' coronary angiogramRecurrent chest tightness or exertional pain after cardiologist cleared a 'normal' coronary angiogram. Explore the earlier tests and three-questiMonthly sore throat, tender neck, and malaise with repeatedly negative strep swabs and normal wbcMonthly sore throat, tender neck, and malaise with repeatedly negative strep swabs and normal WBC. Explore the earlier tests and three-question cPersistent clogged ear, pressure, and hearing your own voice/breathing loud inside your headPersistent clogged ear, pressure, and hearing your own voice/breathing loud inside your head. Compare evidence and try a free three-question reseChronic perineal, testicular, or pelvic pain where repeat courses of ciprofloxacin/doxycycline failChronic perineal, testicular, or pelvic pain where repeat courses of ciprofloxacin/doxycycline fail. Explore the earlier tests and three-questionVaginal burning and discharge returning immediately after fluconazole or metronidazole coursesVaginal burning and discharge returning immediately after fluconazole or metronidazole courses. Compare evidence and try a free three-question reBilateral or asymmetric ankle and lower leg swelling with normal echo, creatinine, and liver functionBilateral or asymmetric ankle and lower leg swelling with normal Echo, Creatinine, and Liver Function. Explore the earlier tests and three-questi
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